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coaA [2019-08-07 10:17:16]
type I pantothenate kinase, major enzyme
function
biosynthesis of coenzyme A
product
pantothenate kinase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.4|Biosynthesis of coenzyme A]Gene
Coordinates
2,468,549 → 2,469,508
The protein
Catalyzed reaction/ biological activity
ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate (according to Swiss-Prot)Protein family
prokaryotic pantothenate kinase family (single member, according to UniProt)Structure
[PDB|1SQ5] (from ''Escherichia coli'', 49% identity, 67% similarity) [Pubmed|15136582]Expression and Regulation
Operons
genes
[gene|35B40D812B123766B469B8E5C0FE0EB69F671E4E|yqjP]-[gene|0927C7D45721F47F5ED2646CAAC324A308FD7724|yqjQ]-[gene|4E7390A74A8261E8B732E94859E90FE256AD64EE|dsdA]-[gene|B3362449EF3C9D533090FBD7E7333A3CC5D902CB|coaA]-[gene|441DCE4251C83FCBB01BC58720900365BFE7BB3D|yqjT]
description
[pubmed|22383849]
Biological materials
Mutant
MGNA-C399 (yqjS::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2397 NBRP B. subtilis, Japan]BKE23760 (Δ[gene|B3362449EF3C9D533090FBD7E7333A3CC5D902CB|coaA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE23760 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGTTTACACCTGACTCT, downstream forward: _UP4_GTGTTGGTAAGGAGGGTATGBKK23760 (Δ[gene|B3362449EF3C9D533090FBD7E7333A3CC5D902CB|coaA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK23760 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGTTTACACCTGACTCT, downstream forward: _UP4_GTGTTGGTAAGGAGGGTATGReferences
